Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Anee Taj; Chen Cui; Zhenwei Shi; Xuebin Huang; Xiao Hui Yang

doi:10.1039/d5qo00926j

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Anee Taj, Chen Cui, Zhenwei Shi, Xuebin Huang^*, Xiao Hui Yang^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

Original language	English
Journal	Organic Chemistry Frontiers
DOIs	http://doi.org/10.1039/d5qo00926j
Publication status	Accepted/In press - 2025

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title = "Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity",

abstract = "Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.",

author = "Anee Taj and Chen Cui and Zhenwei Shi and Xuebin Huang and Yang, \{Xiao Hui\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Royal Society of Chemistry.",

year = "2025",

doi = "10.1039/d5qo00926j",

language = "English",

journal = "Organic Chemistry Frontiers",

issn = "2052-4110",

publisher = "Royal Society of Chemistry",

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T1 - Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

AU - Taj, Anee

AU - Cui, Chen

AU - Shi, Zhenwei

AU - Huang, Xuebin

AU - Yang, Xiao Hui

PY - 2025

Y1 - 2025

N2 - Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

AB - Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

UR - http://www.scopus.com/pages/publications/105018197701

U2 - 10.1039/d5qo00926j

DO - 10.1039/d5qo00926j

M3 - Article

AN - SCOPUS:105018197701

SN - 2052-4110

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

ER -

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Abstract

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